Composition Each tablet contains active ingredients: mecobalamin 0.5 mg, vitamin B1 100 mg and Vitamin B6 200 mg B-cobal Film-coated tablet Composition Each tablet contains active ingredients: mecobalamin 0.5 mg, vitamin B1 100 mg and Vitamin B6 200 mg Indications For neurological and other disorders associated with disturbance of the nerve cell metabolism in which high dose B-complex vitamins play a role. These include: Polyneuritis (of toxic and non toxic etiology): neuralgias eg: lumbago, sciatica, root irritation due to degenerative changes of the vertebral column , shoulder-arm syndrome, herpes zoster, cervical syndrome, ischialgia, etc: diabetic neuropathy; metabolic and neuropathic changes due to pregnancy and oral contraceptives ; convalescence. Megaloblastic anemia due to vitamin B12 deficiency. Dosage Usually for adults, orally administer 1 tab 3 times a day. The dosage should be adjusted according to age of patient and severity of symptoms. Side-effects Gastrointestinal Symptoms, eg anorexia, nausea or diarrhea may occur infrequently. Dermatological: Skin rash may occur rarely. Others: Prolonged use of larger doses of mecobalamin is not recommended to patients whose occupation requires handling of mercury or its compounds. PRECAUTIONS/WARNINGS Cyanocobalamin should not be given before a diagnosis has been fully established because of the possibility of masking symptoms of subacute degeneration of the spinal cord. Cyanocobalamin is not a suitable form of vitamin B12 for the treatment of optic neuropathies associated with raised plasma concentrations of cyanocobalamin. Long term administration of large doses of pyridoxine is associated with the development of severe peripheral neuropathies. This may occur with doses in excess of about 2g daily. Cyanocobalamin should not be used in megaloblastic anaemia of pregnancy. Administration of doses greater than 10 microgram daily may produce a haematological response in patients with folate deficiency. CONTRAINDICATIONS Patients with a history of hypersensitive to vitamin B and mecobalamin